A common mechanism for coenzyme cobalamin-dependent reductive dehalogenases
نویسندگان
چکیده
منابع مشابه
A common mechanism for coenzyme cobalamin-dependent reductive dehalogenases.
Distinct mechanisms have been proposed for the biological dehalogenation catalyzed by cobalamin-dependent enzymes, with two recent crystallographic studies suggesting different mechanisms based on the observed interaction between the organohalide substrate and cobalamin. In one case, involving an aromatic dibromide substrate in NpRdhA, a novel CoII-Br interaction was observed using EPR, suggest...
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Cobamides such as vitamin B12 are structurally conserved, cobalt-containing tetrapyrrole biomolecules that have essential biochemical functions in all domains of life. In organohalide respiration, a vital biological process for the global cycling of natural and anthropogenic organohalogens, cobamides are the requisite prosthetic groups for carbon-halogen bond-cleaving reductive dehalogenases. T...
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ژورنال
عنوان ژورنال: Phys. Chem. Chem. Phys.
سال: 2017
ISSN: 1463-9076,1463-9084
DOI: 10.1039/c6cp08659d